Following September 2025 federal restrictions limiting COVID-19 vaccine eligibility to adults 65+ and high-risk individuals, 18 states implemented protective measures including executive orders allowing pharmacy administration without prescriptions. Regional alliances like the West Coast Health Alliance and Northeast Public Health Collaborative emerged, while Florida moved to eliminate school vaccine mandates. The bipartisan Governor's Public Health Alliance launched October 15 with 15 governors coordinating responses.

Delaware legislators introduced SB 213 eliminating hospital budget oversight authority, while Florida faces court-ordered Medicaid termination pauses after constitutional violations. North Carolina's certificate of need laws face ongoing legal challenges, and New York Governor Hochul proposed $71 million in healthcare investments including mental health licensing reforms. Utah became the first state implementing AI prescription renewals for chronic conditions.

Fifteen governors launched a public health alliance to improve emergency preparedness and coordination across state lines, while CMS announced all 50 states applied for the $50 billion Rural Health Transformation Program. California enacted major healthcare transparency and PBM oversight legislation, Colorado proposed significant Medicaid spending cuts, and Massachusetts advanced prior authorization reforms.

Over the past two months, governors across the country have laid out key policy priorities for the next year in their State of the State addresses. This year, the majority of governors have made healthcare a key issue with several highlighting behavioral health, workforce, and affordability as priorities.